Features and Benefits of the Aguettant System® for Pre-Filled Syringes

The Aguettant System® for Pre-Filled Syringes (PFS) is glassless and needleless reducing risks such as cuts from glass or needlestick injuries for healthcare professionals. Manufactured in a state of the art GMP controlled facility, these Pre-Filled Syringes provide healthcare professionals with the confidence that each one will provide the right drug and the right dose. Outlined below is a chart that illustrates the features and benefits of the Aguettant System® for Pre-Filled Syringes.

Features Benefits
KEY ATTRIBUTES
GMP manufactured and filled Assures it’s the right drug and the right dose. No human preparation error.
Syringe is ready-to-use Reduces preparation time and risk of preparation errors.
No glass No risk of glass cuts or glass particles in medication being injected into patient.
Needle free No needle stick injuries or associated risk of blood borne pathogens.
Reduces waste management costs
3 Year Shelf Life Unopened sterile pack can be saved for later use reducing drug wastage.
PATIENT SAFETY
Latex free components No latex allergies from the syringe.
Preservative free No allergies to a preservative.
STERILITY AND SECURITY
Terminal sterilization of syringe inside blister Minimizing the risk of nosocomial contamination. Pre-filled syringe can be used in a sterile operating field. Sterile connection to luer lock and needle free devices.
Patented dual tamper evident seal and tip cap Assures it’s the right drug and the right dose.
CLEAR LABELLING
Critical product information visible on the syringe Reduces the possibility of medication error due to inadequate identification.
ISO standards colour coded label Aids in identifying correct drug and reducing the possibility of medication errors.
Facilitates standardization across departments in a health care facility.
Graduated dosing scale on both sides of syringe Makes it easy to determine dose administration.
INNOVATIVE DESIGN
Strong, unbreakable polypropylene construction Decreases the risk of injury to health care providers from broken containers.
Integral plunger stop in barrel Reduces risk of accidental plunger removal and loss of drug.
ISO 594 standard molded luer lock Compatible with any luer lock system for infusion or injection.

How long do you think it takes to prepare a syringe from an amploule?

Preparing a syringe from an amploule

How might the Aguettant System® help you save time and reduce risk of preparation injury?

Preparing the Aguettant System® for PFS

SAFETY

Needle Stick Injury

Despite legislation for sharps safety devices and the emphasis on sharps safety training and new safety devices, needle sticks and other sharps continue to pose a risk to healthcare professionals.1

  • The Canadian Needle Stick Surveillance Network reported 3,038 exposures to blood and body fluids from 15 hospitals nationally that voluntarily submitted data between 2008-2012, of which 61% were needle stick injuries.
  • Nurses and doctors reported more than 67% of the sharps injuries and were placed at risk of catching a blood borne pathogen like hepatitis B, hepatitis C or HIV.1

The Aguettant System for pre-filled syringes is needleless and has a sterile luer lock connector for connection to any medication system that uses a luer lock, thus eliminating the risk of injury and exposure to blood borne pathogens via a needle stick.

  1. Canadian Needle Stick Surveillance Network Final Program Report , Jan 2008 – June 2012
    http://publications.gc.ca/collections/collection_2014/aspc-phac/HP40-88-2013-eng.pdf

Glass Injury

The opening technique of an ampoule requires that the top of the glass ampoule be broken off by hand, leaving sharp edges which can result in topical hand injury to the health care practitioner.

  • Parker investigated the risk of injury from glass ampoules in a UK hospital in 1995, and found that during the 97 anaesthetic sessions evaluated there was a 6% incidence of glass injury. The researcher also found that 26% of the anaesthetists had evidence of previous hand lacerations attributed to opening glass ampoules.1
  • A 2003 study by Lye and Hwangl, looked at glass particles remaining in ampoules after the ampoules were opened. Investigators found that even with an 18G needle for drawing up the contents of the ampoules, smaller glass particles can still pass through the needle into the syringe and could easily be injected into a patient.2 In 2011,Carraretto et al in Brazil found no protective effect by using filter needles to screen out glass particles, just increased cost.3

The Aguettant System® for Pre-Filled Syringes is made from durable plastic, eliminating the preparation risk of handling broken glass for both staff and patients.

  1. Parker M.R.J., The use of protective gloves, the incidence of ampoule injury and prevalence of hand laceration amongst anesthetic personnel, Anaesthesia, 1995, Aug 50 (8): 726-729
  2. S T Lye and N C Hwng, Glass Particle contamination is it here to stay?, Anaesthesia, vol 58 Issue 1 p93-94 Jan 2003
  3. Carraretto A. R.,Curi E. F., De Almaeida C. E. D., Abatti, R.E.M., Glass ampoules: Risks and Benefits, Revista. Brasileira de Anestesiologia, 2011:61, 513-521

HUMAN FACTORS

Preparation/Administration Errors

The task of preparing and administering an IV drug to a patient during anaesthesia/emergency setting is a complex process. This takes place in a stressful environment which potentially leads to errors in the preparation of the medication due to human factors such as haste, fatigue and communication failure.1

  • Abeysekera et al in 2004 performed a review of reports of drug error in anaesthesia in an Australian university hospital and found that of 896 reports, 452 were syringe and drug preparation errors, accounting for 50% of the cases.1
  • The same hospital study found that ampoule and labeling mistakes accounted for 20% of all errors. The authors suggested that the use of pre-filled syringes could remove these errors.1
  • In a UK anaesthesia IV drug preparation observational study in 2003 , Katja and Barber found 212 errors in preparation and administration out of 430 IV drug doses (49%).2

The Aguettant System® for pre-filled syringes is GMP prepared with an ISO Standard colour coded label for anaesthesiology and dual graduations on both sides of the syringe to ensure clear identification. These features ensure the right drug in the right amount, eliminating the risks of common human preparation errors.

  1. Abeysekera A., Bergman I.J., Kluger M.T., Short T.G., Drug Error in anaesthetic practice: a review of 896 reports from the Australian Incident Monitoring Study Database, Anesthesia, 2005, 60, pages 220-227
  2. Katja Taxis, Nick Barber, Ethnographic study of incidence and severity of intravenous drug errors, BMJ vol 326. 29 Mar 2003

WASTAGE

Wastage is prevalent with IV drugs & supplies due to sterility and contamination concerns which cause partly used or unused prepared products to be disposed of.1,3 Furthermore some supplies require special waste management, such as sharps which goes into bio-hazard waste, costing more than regular waste.4

  • In a US hospital in 2000, Gillerman and Browning2, estimated the cost of anaesthetic waste of just 6 drugs to be $165,667 accounting for the 26% of the department’s total drug cost. The reason most cited for the wastage was the disposal of full or partially full prepared syringes.
  • In investigating the wastage of operating room supplies and drugs in US hospitals in 2009, Esaki and Macario, found that dealing with the extra needles and drug of discarded products is an additional cost.3
  • A CMAJ article by Kagoma et al in 2012 estimated that the disposal of biohazard waste is 8 times that of normal solid waste.4

The Aguettant System® for PFS contains no needle and is ready-to-use. This eliminates the need for biohazard waste disposal, preparation supplies disposal, and the disposal of prepared but unused drug.

  1. Hannah Dee, Drug and Material Wastage in Anesthesia Care, The Georgetown Undergraduate Journal of Health Sciences 6 (2), 2012,
  2. Gillerman R G., Browning R .A., Drug Use Inefficiency: A Hidden Source of Wasted Health Care Dollars, Anesthesia & Analgesia 2000:91: 921-4
  3. Roy K. Esaki, MD, Alex Macario, MD, Wastage of Supplies and Drugs in the Operating Room
    Medscape Anesthesiology , Oct 21 2009, http://www.medscape.com/viewarticle/710513
  4. Kagoma Y et al, People, planet and profits: the case for greening operating rooms, CMAJ, Nov 20 2012, 184(17), CMAJ. DOI:10.1503/cmaj.112139

COSTS

Anaesthesiology procedures typically require the preparation of medications in anticipation of emergency use. Some of these are prepared but not used, and must be discarded at the end of the procedure, resulting in wastage with associated costs.1

  • Several studies have demonstrated that 84% - 92% of atropine syringes prepared from ampoules and vials are discarded as waste because of concerns relating to stability, correct labeling, and sterility.1,2,3,4
  • A June 2014 budget impact model of pre-filled syringes of atropine in France identified the true cost of a prepared syringe of atropine should include the ampoule, the cost of all the materials used to prepare it, the cost of preparation time, the waste cost of prepared but unused syringes, and the cost of waste treatment of drug, needles, syringes and other supplies.4

The Aguettant System® for pre-filled syringe is ready-to-use, eliminating preparation costs and medication preparation error costs. It’s plastic and needleless, eliminating the cost of breakage or sharps injury and can be disposed of as regular waste. Its sterile blister pack allows unused unopened product to be put back into inventory, eliminating drug waste.

  1. Goulding et al, Pre-filled emergency drugs: The introduction of pre-filled metarminol and
    ephedrine syringes into the main operating theatres of a major metropolitan centre, Australian Anaesthesia 2013, pg 127-134
  2. Lejus C et al, Atropine and ephedrine: a significant waste in the operating theatre, Anesthesia 2012, 67, 294 -308
  3. Bellefleur J-P, et al. Use of ephedrine prefilled syringes reduces anaesthesia costs, Ann.Fr
    Anaesth Reanim (2009), doi: 10.1016/j.annfar.2008.12.004
  4. Budget Impact Model of Pre-Filled Syringes of Atropine- June 10, 2014

Call BioSyent Pharma to find out what drugs are in the Aguettant System® for Pre-Filled Syringe.